Discovery of a new protein that may rival "Ozempic" with fewer side effects
Would you like to try a new way to lose weight? 🤔 Scientists from Stanford University may have found a promising solution: a new protein called BRP, which could rival the popular drug "Ozempic" in this field.
BRP (BRINP2-related peptide) is a naturally occurring molecule that helps control appetite and promote weight loss by activating certain nerve cells in the brain, similar to the drug Ozempic. However, BRP follows a different metabolic pathway, which may make it a safer alternative.
Researchers used an AI-based program to identify 373 proteins for investigation, narrowing them down to 100 potential peptides that influence appetite. Among these, they focused on BRP, which consists of only 12 amino acids.
Animal studies (mice and pigs) have shown promising results: BRP injections reduced food intake by almost half and led to an average weight loss of 4 grams in obese mice over 14 days, without any noticeable side effects such as nausea. This weight loss was primarily from body fat, not muscle.
This discovery underscores the importance of ongoing research in the fight against obesity and raises questions about the long-term effects of weight-loss medications, particularly on heart health. Further research is needed to determine the precise impacts on human health.
Why is BRP interesting?
Because it activates metabolic and neurological pathways that are completely different from those of "Ozempic", BRP may be less affected by side effects such as nausea and constipation, which accompany the use of GLP-1 drugs. This is what distinguishes it and makes it promising as a possible alternative.
Further clinical trials will be conducted on humans to assess the safety and efficacy of BRP before it is released to the market. 💸
With obesity rates rising globally, developing effective, safe, and efficient weight-loss drugs presents a major scientific challenge. Is BRP the answer?
This study was published in the journal Nature .
Source: Original website